Our laboratory is interested in understanding the basic mechanisms of human immune syndromes. Since a healthy immune system is essential in fighting off pathogens and diseases, an imbalance of the immune system can lead to devastating diseases. For example, the lack of a properly developed immune system exposes the body to pathogens, while an overly active immune system can lead to autoimmune diseases. We are interested in understanding the development and function of a key educational organ system, the thymus, in this context. To this end, we use pluripotent stem cells to recapitulate the development of thymic epithelial cells and to construct stem cell-based human immune disease models.